Chaga Mushroom

Anti-Cancer, and Chemotherapy Studies

• Chaga mushroom extract induces autophagy via the AMPK-mTOR signaling pathway in breast cancer cells

• Continuous intake of the Chaga mushroom (Inonotus obliquus) aqueous extract suppresses cancer progression and maintains body temperature in mice

• Optimization of ultrasonic/microwave assisted extraction (UMAE) of polysaccharides from Inonotus obliquus and evaluation of its anti-tumor activities

• Inonotus obliquus Polysaccharide Ameliorates Azoxymethane/Dextran Sulfate Sodium-Induced Colitis-Associated Cancer in Mice via Activation of the NLRP3 Inflammasome

• Cancer Cell Cytotoxicity of Extracts and Small Phenolic Compounds from Chaga [Inonotus obliquus(persoon) Pilat]

Anti-Fatigue Studies

• Effect of Inonotus Obliquus Polysaccharides on physical fatigue in mice

Anti-Inflammation Studies

• Anti-inflammatory effect ofInonotus obliquus,Polygala senegaL., andViburnum trilobumin a cell screening assay

• Bioactive triterpenoids and water-soluble melanin fromInonotus obliquus(Chaga) with immunomodulatory activity

Antioxidant Studies

• Optimization for the extraction of polyphenols fromInonotus obliquusand its antioxidation activity

Anti-Viral Studies

• Aqueous extract from a Chaga medicinal mushroom, Inonotus obliquus (higher Basidiomycetes), prevents herpes simplex virus entry through inhibition of viral-induced membrane fusion

Gut Microbiome Studies

• The difference of regulatory effect of two Inonotus obliquus extracts on high-fat diet mice in relation to the fatty acid elongation function of gut microbiota

Immune System Studies

• Purification, characterization and biological activity of a novel polysaccharide from Inonotus obliquus

Cordyceps Mushroom

Anti-Aging Studies

• Antiaging effect of Cordyceps sinensis extract

Anti-Cancer Studies

• The Novel Nucleoside Analogue ProTide NUC-7738 Overcomes Cancer Resistance MechanismsIn Vitroand in a First-In-Human Phase I Clinical Trial

Anti-Hyperglycemic Studies

• The anti-hyperglycemic activity of the fruiting body of Cordyceps in diabetic rats induced by nicotinamide and streptozotocin

Anti-Inflammatory Studies

• Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis

Athletic Performance Studies

• Cordyceps Sinensis (CordyMax Cs-4) Supplementation Does Not Improve Endurance Exercise Performance

• Beneficial Effect of Cordyceps militarison Exercise Performance via Promoting Cellular Energy Production

• Chronic supplementation of a mushroom blend on oxygen kinetics, peak power, and time to exhaustion

• Antifatigue and antistress effect of the hot-water fraction from mycelia of Cordyceps sinensis

Heart Health Studies

• Cordycepin, 3'-deoxyadenosine, prevents rat hearts from ischemia/reperfusion injury via activation of Akt/GSK-3β/p70S6K signaling pathway and HO-1 expression

Immune Studies

• Cordycepin is an immunoregulatory active ingredient of Cordyceps sinensis

• Comparison of protective effects between cultured Cordyceps militaris and natural Cordyceps sinensis against oxidative damage

Sexual Performance Research

• Effects of CulturedCordycep militarison Sexual Performance and Erectile Function in Streptozotocin-Induced Diabetic Male Rats

Lion's Mane Mushroom

Cognition, Neuroregenisis, and Alzheimer’s Research

• Prevention of Early Alzheimer’s Disease by Erinacine A-EnrichedHericium erinaceusMycelia Pilot Double-Blind Placebo-Controlled Study

• The Anti-Dementia effect of Lion's Mane mushroom (Hericium erinaceum) and its clinical application

• Neurological Activity of Lion’s Mane (Hericium erinaceus)

• Neuroregenerative potential of lion's mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (higher Basidiomycetes), in the treatment of peripheral nerve injury (review)

• Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial

• Erinacines A, B and C, strong stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum

• Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice

Immunity and Anti-Cancer Studies

• Antitumor and immunoenhancing activities of polysaccharide from culture broth of Hericium spp

• Hericium erinaceus (Lion's Mane) mushroom extracts inhibit metastasis of cancer cells to the lung in CT-26 colon cancer-tansplanted mice

Stress Management, Depression, and Mood Studies

• Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake

• Therapeutic Potential ofHericium erinaceusfor Depressive Disorder

• Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice

Reishi Mushroom

Immune System and Cancer Research

• Reishi (Ganoderma lucidum)

• Ganoderma lucidum(Reishi) suppresses proliferation and migration of breast cancer cells via inhibiting Wnt/β-catenin signaling

• Ganoderma lucidumExtract Reduces the Motility of Breast Cancer Cells Mediated by the RAC–Lamellipodin Axis

• Monitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancer

• Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients

• Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial

Neuroprotective Benefits

• Ganoderma lucidum extract ameliorates MPTP-induced parkinsonism and protects dopaminergic neurons from oxidative stress via regulating mitochondrial function, autophagy, and apoptosis

• Aromatic constituents from Ganoderma lucidum and their neuroprotective and anti-inflammatory activities

• Polysaccharides from Ganoderma lucidum attenuate microglia-mediated neuroinflammation and modulate microglial phagocytosis and behavioural response

Obesity Management and Metabolic Health

• Medicinal mushroom reduces obesity by modulating microbiota

• Suppression of obesity and inflammation by polysaccharide from sporoderm-broken spore of Ganoderma lucidum via gut microbiota regulation

• Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice

Sleep Benefits

• Ganoderma lucidumpromotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice

• Extract of Ganoderma lucidum prolongs sleep time in rats

Stress Management, Depression, and Mood Studies

• A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia

• Ganoderma lucidum polysaccharides ameliorated depression-like behaviors in the chronic social defeat stress depression model via modulation of Dectin-1 and the innate immune system

• Ganoderma Lucidum Triterpenoids Improve Maternal Separation-Induced Anxiety- and Depression-like Behaviors in Mice by Mitigating Inflammation in the Periphery and Brain

• Ganoderma lucidumEffects on Mood and Health-Related Quality of Life in Women with Fibromyalgia

Turkey Tail Mushroom

Anti-oxidant Properties

• The lignicolous fungusTrametes versicolor(L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents

• Antioxidative activities and chemical characterization of polysaccharide extracts from the widely used mushroomsGanoderma applanatum,Ganoderma lucidum,Lentinus edodesandTrametes versicolor

• Screening and comparison of antioxidant activities of polysaccharides from Coriolus versicolor

Diabetes Research

• Extracellular Polysaccharopeptides from Fermented Turkey Tail Medicinal Mushroom, Trametes versicolor (Agaricomycetes), Mitigate Oxidative Stress, Hyperglycemia, and Hyperlipidemia in Rats with Type 2 Diabetes Mellitus

• Potential activities and mechanisms of extracellular polysaccharopeptides from fermented Trametes versicolor on regulating glucose homeostasis in insulin-resistant HepG2 cells

Gut Biome and Digestion

• Coriolus versicolor suppresses inflammatory bowel disease by Inhibiting the expression of STAT1 and STAT6 associated with IFN-γ and IL-4 expression

• Trametes versicolor extract modifies human fecal microbiota composition in vitro

Immune System and Cancer Research

• Turkey Tail and Polysaccharide-K

• Phase 1 Clinical Trial ofTrametes versicolorin Women with Breast Cancer

• FDA Approves Bastyr Turkey Tail Trial for Cancer Patients

• Efficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer. Study Group of Immunochemotherapy with PSK for Gastric Cancer

• Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curatively resected colorectal cancer: a meta-analysis of centrally randomized controlled clinical trials

• Trametes versicolor(Synn.Coriolus versicolor) Polysaccharides in Cancer Therapy: Targets and Efficacy

Vaginal Health and HPV Studies

• Efficacy of aCoriolus versicolor–Based Vaginal Gel in Women With Human Papillomavirus–Dependent Cervical Lesions: The PALOMA Study

• Control of oral human papillomavirus (HPV) by medicinal mushrooms, Trametes versicolor and Ganoderma lucidum: a preliminary clinical trial